Document Detail


Yeast mating: a model system for studying cell and nuclear fusion.
MedLine Citation:
PMID:  18979235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Haploid yeast cells mate to form a zygote, whose progeny are diploid cells. A fundamentally sexual event, related to fertilization, yeast mating nevertheless exhibits cytological properties that appear similar to somatic cell fusion. A large collection of mutations that lead to defects in various stages of mating, including cell fusion, has allowed a detailed dissection of the overall pathway. Recent advances in imaging methods, together with powerful methods of genetic analysis, make yeast mating a superb platform for investigation of cell fusion. An understanding of yeast cell fusion will provide insight into fundamental mechanisms of cell signaling, cell polarization, and membrane fusion.
Authors:
Casey A Ydenberg; Mark D Rose
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  475     ISSN:  1064-3745     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-03     Completed Date:  2008-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-20     Citation Subset:  IM    
Affiliation:
Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
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MeSH Terms
Descriptor/Qualifier:
Cell Adhesion
Cell Membrane / metabolism
Cell Nucleus / metabolism*
Cell Polarity
Cell Wall / metabolism
Membrane Fusion*
Models, Biological*
Pheromones / metabolism
Reproduction
Saccharomyces cerevisiae / cytology*,  physiology
Signal Transduction
Chemical
Reg. No./Substance:
0/Pheromones

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