Document Detail

Yeast longevity and aging--the mitochondrial connection.
MedLine Citation:
PMID:  15621203     Owner:  NLM     Status:  MEDLINE    
Studies of the yeast Saccharomyces cerevisiae reveal four processes determining life span: metabolism, stress resistance, chromatin-dependent gene regulation, and genome stability. The retrograde response, which signals mitochondrial dysfunction resulting in changes in nuclear gene expression, extends yeast life span and is induced during normal aging. This response involves extensive metabolic adaptations. The retrograde response links metabolism and genome stability during yeast aging. A reduction in the availability of nutrients also extends yeast life span. This metabolic mechanism operates by pathways distinct from the retrograde response, although it shares with the latter some longevity effectors. Life extension by calorie restriction entails re-modeling of mitochondrial function. The retrograde response appears to compensate for age changes, while calorie restriction may be a preventive mechanism. The maintenance of age asymmetry between the mother and daughter yeast cells also depends on mitochondrial function. Loss of this age asymmetry occurs during normal yeast aging and may be a paradigm for stem cell aging. The importance of mitochondrial integrity in yeast longevity is emphasized by the role of prohibition function in attenuating oxidative damage. Our studies point to the central role of mitochondria in yeast aging. They highlight the importance of the maintenance of mitochondrial membrane potential, which drives the transport of biosynthetic precursors derived from the Krebs cycle. Common threads weave their way through the studies of aging in yeast and in other model organisms. This suggests conserved features of aging across phyla.
S Michal Jazwinski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  126     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  243-8     Citation Subset:  IM    
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7-2, New Orleans, LA 70112, USA.
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MeSH Terms
Caloric Restriction
Fungal Proteins / physiology*
Gene Expression Regulation, Fungal
Genes, Fungal
Membrane Potentials
Mitochondria / metabolism,  pathology*
Models, Biological
Reactive Oxygen Species
Saccharomyces cerevisiae / metabolism*
Saccharomyces cerevisiae Proteins / physiology*
Stem Cells / cytology,  pathology
Time Factors
Yeasts / metabolism
Reg. No./Substance:
0/Fungal Proteins; 0/Reactive Oxygen Species; 0/Saccharomyces cerevisiae Proteins

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