Document Detail

Yeast as a model organism for studying the evolution of non-standard genetic codes.
MedLine Citation:
PMID:  15163358     Owner:  NLM     Status:  MEDLINE    
During the last 30 years, a number of alterations to the standard genetic code have been uncovered both in prokaryotes and eukaryotic nuclear and mitochondrial genomes. But, the study of the evolutionary pathways and molecular mechanisms of codon identity redefinition has been largely ignored due to the assumption that non-standard genetic codes can only evolve through neutral evolutionary mechanisms and that they have no functional significance. The recent discovery of a genetic code change in the genus Candida that evolved through an ambiguous messenger RNA decoding mechanism is bringing that naive assumption to an abrupt end by showing, in a rather dramatic way, that genetic code changes have profound physiological and evolutionary consequences for the species that redefine codon identity. In this paper, the recent data on the evolution of the Candida genetic code are reviewed and an experimental framework based on forced evolution, molecular genetics and comparative and functional genomics methodologies is put forward for the study of non-standard genetic codes and genetic code ambiguity in general. Additionally, the importance of using Saccharomyces cerevisiae as a model organism for elucidating the evolutionary pathway of the Candida and other genetic code changes is emphasised.
Raquel M Silva; Isabel Miranda; Gabriela Moura; Manuel A S Santos
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Briefings in functional genomics & proteomics     Volume:  3     ISSN:  1473-9550     ISO Abbreviation:  Brief Funct Genomic Proteomic     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-05-27     Completed Date:  2004-12-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101150306     Medline TA:  Brief Funct Genomic Proteomic     Country:  England    
Other Details:
Languages:  eng     Pagination:  35-46     Citation Subset:  IM    
Functional Evolutionary Genomics Laboratory of the Centre for Cell Biology, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.
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MeSH Terms
Candida / genetics*
Evolution, Molecular
Genetic Code*
Models, Biological
RNA / metabolism
Saccharomyces cerevisiae / genetics*
Yeasts / genetics
Reg. No./Substance:
0/Codon; 0/Proteome; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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