Document Detail


Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation.
MedLine Citation:
PMID:  1516834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Jun and Fos oncoproteins belong to the AP-1 family of transcriptional activators and are believed to induce cellular transformation by inappropriately activating genes involved in cell replication. To determine whether transcriptional activation through AP-1 sites is sufficient for transforming activity, we examined the properties of an autonomous and heterologous AP-1 protein, yeast GCN4, in rat embryo fibroblasts. GCN4 induces transcriptional activation through AP-1 sites but, unlike Jun and Fos, fails to induce cellular transformation, in cooperation with Ha-ras. Jun-GCN4 and Fos-GCN4 homodimers independently induce cellular transformation indicating that the amino-terminal regions of Jun and Fos each contain regulatory functions that are required for oncogenesis but are distinct from generic transcriptional activation domains. In addition, these observations have implications for the nature of the oncogenically relevant target genes that respond to Jun and Fos.
Authors:
S Oliviero; G S Robinson; K Struhl; B M Spiegelman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genes & development     Volume:  6     ISSN:  0890-9369     ISO Abbreviation:  Genes Dev.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-10-07     Completed Date:  1992-10-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1799-809     Citation Subset:  IM    
Affiliation:
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Cell Transformation, Neoplastic / genetics*
Cells, Cultured
DNA-Binding Proteins / chemistry,  genetics*
Fungal Proteins / chemistry,  genetics*
Humans
Molecular Sequence Data
Protein Kinases*
Proto-Oncogene Proteins c-fos / chemistry,  genetics*
Proto-Oncogene Proteins c-jun / chemistry,  genetics*
Recombinant Fusion Proteins / chemistry,  genetics
Saccharomyces cerevisiae Proteins*
Transcription Factors / chemistry,  genetics*
Transcription, Genetic / genetics
Grant Support
ID/Acronym/Agency:
GM30186/GM/NIGMS NIH HHS; GM46555/GM/NIGMS NIH HHS; HD 24926/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Fungal Proteins; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Recombinant Fusion Proteins; 0/Saccharomyces cerevisiae Proteins; 0/Transcription Factors; EC 2.7.-/Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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