| YY1 Controls Immunoglobulin Class Switch Recombination and Nuclear AID Levels. | |
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MedLine Citation:
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PMID: 22290437 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Activation induced deaminase (AID) is an enzyme required for class switch recombination (CSR) and somatic hypermutation (SHM), processes that ensure antibody maturation and expression of different immunoglobulin isotypes. AID function is tightly regulated by tissue-and stage-specific expression, nuclear localization, and protein stability. Transcription factor YY1 is crucial for early B cell development, but its function at late B cell stages is unknown. Here we show that YY1 conditional knock-out in activated splenic B cells interferes with CSR. Knock-out of YY1 did not affect B cell proliferation, transcription of the AID and IgM genes, or levels of various switch region germline transcripts. However, we show that YY1 physically interacts with AID and controls accumulation of nuclear AID at least in part, by increasing nuclear AID stability. We show for the first time that YY1 plays a novel role in CSR and controls nuclear AID protein levels. |
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Authors:
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Kristina Zaprazna; Michael L Atchison |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-30 |
Journal Detail:
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Title: Molecular and cellular biology Volume: - ISSN: 1098-5549 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109087 Medline TA: Mol Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Pennsylvania, School of Veterinary Medicine, Department of Animal Biology, 3800 Spruce Street, Philadelphia, PA 19104. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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