Document Detail


YKL-40 a new biomarker in patients with acute coronary syndrome or stable coronary artery disease.
MedLine Citation:
PMID:  18615353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: YKL-40 is involved in remodelling and angiogenesis in non-cardiac inflammatory diseases. Aim was to quantitate plasma YKL-40 in patients with ST-elevation myocardial infarction (STEMI) or stable chronic coronary artery disease (CAD), and YKL-40 gene activation in human myocardium. METHODS AND RESULTS: We included 73 patients: I) 20 patients with STEMI; II) 28 patients with stable CAD; III) 15 CAD patients referred for coronary by-pass surgery. YKL-40 mRNA expression was measured in myocardium subtended by stenotic or occluded arteries and areas with no apparent disease; and IV) 10 age-matched healthy controls. Plasma YKL-40 was significantly increased in patients with STEMI (88 microg/l, median) and CAD (66 microg/l) compared to controls (16 microg/l, p<0.01 for both). Plasma YKL-40 correlated with CRP at baseline in STEMI (r=0.53, p=0.02) and CAD patients (r=0.41, p=0.031).YKL-40 gene expression was similar in ischemic and non-ischemic myocardium. CONCLUSIONS: Plasma YKL-40 was significantly increased in patients with STEMI and stable CAD. Further studies will define the role of YKL-40 as a clinically useful marker for myocardial ischemia, remodelling and maybe prognosis.
Authors:
Yongzhong Wang; Rasmus Sejersten Ripa; Julia Sidenius Johansen; Anders Gabrielsen; Daniel A Steinbruchel; Tina Friis; Lene Bindslev; Mandana Haack-Sørensen; Erik Jørgensen; Jens Kastrup
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  42     ISSN:  1651-2006     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-19     Completed Date:  2009-01-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  England    
Other Details:
Languages:  eng     Pagination:  295-302     Citation Subset:  IM    
Affiliation:
Medical Department B, Cardiac Catheterization Laboratory, The Heart Centre, Rigshospitalet, University Hospital Copenhagen, Faculty of Health Sciences, University of Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / blood*
Aged
Biological Markers / blood
Case-Control Studies
Coronary Artery Disease / blood*
Female
Gene Expression
Glycoproteins / blood*
Humans
Lectins
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CHI3L1 protein, human; 0/Glycoproteins; 0/Lectins

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