Document Detail

YKL-40 levels in the cerebrospinal fluid and serum of patients with aneurysmal subarachnoid hemorrhage: preliminary results.
MedLine Citation:
PMID:  16153848     Owner:  NLM     Status:  MEDLINE    
YKL-40 is a newly discovered matrix protein thought to be secreted during the acute stages of inflammation. Clinical studies have revealed that YKL-40 has growth factor and potent migration factor activity for cells involved in inflammation and tissue remodeling processes. It has recently been speculated that YKL-40 may serve as a specific serologic marker of neutrophil function at the site of acute tissue inflammation. We aimed to quantify the levels of YKL-40 in both cerebrospinal fluid and serum of ten consecutive patients with aneurysmal subarachnoid hemorrhage and to speculate on the origin of this glycoprotein. The levels were also compared with ten control patients with hydrocephalus. We found that patients with aneurysmal subarachnoid hemorrhage had significantly higher YKL-40 levels in both cerebrospinal fluid and serum than controls. The authors believe that YKL-40 is expressed in cerebrospinal fluid due to stress on neural structures while a damaged blood-brain barrier allows entry of neutrophils and macrophages from the systemic circulation.
Mehmet Yasar Kaynar; Taner Tanriverdi; Ali Metin Kafadar; Tibet Kacira; Fatma Yurdakul; Hafize Uzun; Koray Gumustas
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  12     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2006-05-25     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  754-7     Citation Subset:  IM    
Department of Neurosurgery; Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.
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MeSH Terms
Case-Control Studies
Enzyme-Linked Immunosorbent Assay / methods
Glycoproteins / blood*,  cerebrospinal fluid*
Middle Aged
Retrospective Studies
Statistics, Nonparametric
Subarachnoid Hemorrhage / blood*,  cerebrospinal fluid*
Time Factors
Reg. No./Substance:
0/CHI3L1 protein, human; 0/Glycoproteins; 0/Lectins

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