| YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation. | |
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MedLine Citation:
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PMID: 2961059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The invasion of tumor cells through basement membranes is a critical step in the formation of metastases. The binding of the malignant cells to laminin in the basement membranes allows their attachment and activates their invasiveness. Recently a synthetic nonapeptide from the B1 chain sequence of laminin was identified as a major site for cell binding. A pentapeptide within the nonapeptide sequence was found to reduce the formation of lung colonies in mice injected with melanoma cells and also to inhibit the invasiveness of the cells in vitro. |
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Authors:
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Y Iwamoto; F A Robey; J Graf; M Sasaki; H K Kleinman; Y Yamada; G R Martin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 238 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1987 Nov |
Date Detail:
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Created Date: 1987-12-23 Completed Date: 1987-12-23 Revised Date: 2007-03-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1132-4 Citation Subset: IM |
Affiliation:
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Laboratory of Developmental Biology and Anomalies, National Institute of Drug Research, Bethesda, MD 20892. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basement Membrane / physiopathology Binding Sites Cell Adhesion / drug effects* Laminin* Lung Neoplasms / secondary Melanoma, Experimental / pathology, physiopathology Mice Neoplasm Metastasis / prevention & control* Oligopeptides / chemical synthesis*, pharmacology Receptors, Immunologic / drug effects* Receptors, Laminin Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Laminin; 0/Oligopeptides; 0/Receptors, Immunologic; 0/Receptors, Laminin |
| Comments/Corrections | |
Erratum In:
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Science 1988 Jan 15;239(4837):245 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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