Document Detail

YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation.
MedLine Citation:
PMID:  2961059     Owner:  NLM     Status:  MEDLINE    
The invasion of tumor cells through basement membranes is a critical step in the formation of metastases. The binding of the malignant cells to laminin in the basement membranes allows their attachment and activates their invasiveness. Recently a synthetic nonapeptide from the B1 chain sequence of laminin was identified as a major site for cell binding. A pentapeptide within the nonapeptide sequence was found to reduce the formation of lung colonies in mice injected with melanoma cells and also to inhibit the invasiveness of the cells in vitro.
Y Iwamoto; F A Robey; J Graf; M Sasaki; H K Kleinman; Y Yamada; G R Martin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  238     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-23     Completed Date:  1987-12-23     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1132-4     Citation Subset:  IM    
Laboratory of Developmental Biology and Anomalies, National Institute of Drug Research, Bethesda, MD 20892.
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MeSH Terms
Basement Membrane / physiopathology
Binding Sites
Cell Adhesion / drug effects*
Lung Neoplasms / secondary
Melanoma, Experimental / pathology,  physiopathology
Neoplasm Metastasis / prevention & control*
Oligopeptides / chemical synthesis*,  pharmacology
Receptors, Immunologic / drug effects*
Receptors, Laminin
Structure-Activity Relationship
Reg. No./Substance:
0/Laminin; 0/Oligopeptides; 0/Receptors, Immunologic; 0/Receptors, Laminin
Erratum In:
Science 1988 Jan 15;239(4837):245

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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