| A YIDD Mutation in a Case of Recurrent Hepatitis B after Liver Transplantation Induced by an S-escape Mutant. | |
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MedLine Citation:
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PMID: 20559531 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A 47-year-old woman underwent orthotopic liver transplantation (OLT) for hepatitis B virus (HBV)-related end-stage liver cirrhosis. The patient received hepatitis B immunoglobulin prophylaxis after OLT. Despite the protective level of the serum anti-hepatitis-B surface antibody, HBV recurred at 22 months post-OLT and induced subacute hepatic failure. The pre-OLT HBV genome contained a complex mutation pattern in overlapping frame regions of the surface (S) and polymerase (P) genes, which is the same mutation pattern as seen in post-OLT HBV DNA. G145R and K141R mutations in the "a" determinant were detected only in the post-OLT sample. Clevudine (30 mg once daily) was administered for recurrent hepatitis B. Hepatitis B was reactivated with a flare-up, and a M204I mutation (YIDD mutant type) appeared with a higher viral load at 9 months after clevudine treatment. We report here a case of a YIDD mutation that developed in recurrent hepatitis B after OLT induced by an S-escape mutant. |
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Authors:
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Yun-Jung Oh; Young-Min Park; Sun-Pyo Hong; Soo-Kyeong Shin; Seung-Il Ji; Bo-Hyun Kim; Sang-Jong Park; Zheng Hong |
Publication Detail:
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Type: Journal Article Date: 2010-06-16 |
Journal Detail:
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Title: Gut and liver Volume: 4 ISSN: 1976-2283 ISO Abbreviation: Gut Liver Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101316452 Medline TA: Gut Liver Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 253-7 Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Bundang Jesang General Hospital, Daejin Medical Center, Seongnam, Korea. |
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