| YB-1: oncoprotein, prognostic marker and therapeutic target? | |
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MedLine Citation:
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PMID: 23216250 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Hanahan and Weinberg have proposed the 'hallmarks of cancer' to cover the biological changes required for the development and persistence of tumours [Hanahan and Weinberg (2011) Cell 144, 646-674]. We have noted that many of these cancer hallmarks are facilitated by the multifunctional protein YB-1 (Y-box-binding protein 1). In the present review we evaluate the literature and show how YB-1 modulates/regulates cellular signalling pathways within each of these hallmarks. For example, we describe how YB-1 regulates multiple proliferation pathways, overrides cell-cycle check points, promotes replicative immortality and genomic instability, may regulate angiogenesis, has a role in invasion and metastasis, and promotes inflammation. We also argue that there is strong and sufficient evidence to suggest that YB-1 is an excellent molecular marker of cancer progression that could be used in the clinic, and that YB-1 could be a useful target for cancer therapy. |
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Authors:
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Annette Lasham; Cristin G Print; Adele G Woolley; Sandra E Dunn; Antony W Braithwaite |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 449 ISSN: 1470-8728 ISO Abbreviation: Biochem. J. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: England |
Other Details:
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Languages: eng Pagination: 11-23 Citation Subset: IM |
Affiliation:
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*Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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