Document Detail


A YAC contig spanning the dominant retinitis pigmentosa locus (RP9) on chromosome 7p.
MedLine Citation:
PMID:  7490071     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The dominant retinitis pigmentosa locus RP9 has previously been localized to 7p13-p15, in the interval D7S526-D7S484. We now report refinement of the locus to the interval D7S795-D7S484 and a YAC contig of approximately 4.8 Mb spanning this region and extending both distally and proximally from it. The contig was constructed by STS content mapping and physically orders 29 STSs in 28 YAC clones. The order of polymorphic markers in the contig is consistent with a genetic map that has been assembled using haplotype data from the CEPH pedigrees. This contig will provide a primary resource for the construction of a transcriptional map of this region and for the identification of the defective gene causing this form of adRP.
Authors:
T J Keen; C F Inglehearn; E D Green; A F Cunningham; R J Patel; R E Peacock; S Gerken; R White; J Weissenbach; S S Bhattacharya
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  28     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-01-03     Completed Date:  1996-01-03     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  383-8     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetics, Institute of Ophthalmology, London, United Kingdom.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/G00382;  G01545;  G05104;  G05166;  U10571;  U10572;  U10573;  U10574;  U10575;  U10576;  U15299
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Chromosome Mapping
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 7*
DNA Primers
Female
Humans
Male
Molecular Sequence Data
Pedigree
Retinitis Pigmentosa / genetics*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/DNA Primers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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