Document Detail

The Y* rearrangement in mice: new insights into a perplexing PAR.
MedLine Citation:
PMID:  9678332     Owner:  NLM     Status:  MEDLINE    
In essence, the Y* rearrangement in the mouse is a Y chromosome that has been hijacked by a non-Y centromere attached distal to the pseudoautosomal region (PAR). All the Y-unique material is thought to be unaltered, but the recombinatory behaviour of the Y* with the X during male meioisis led to the conclusion that part of the PAR is inverted. In the course of a cross set up to introduce the X-linked mutation Patchy fur (Paf) into XY* males, the Y* chromosome was found to carry the wild type allele of Paf. Paf maps close to the X PAR boundary, so we hypothesised that the inverted region of the Y* PAR originated from an X chromosome that provided not only an inverted copy of proximal PAR, but also an X PAR boundary together with some adjacent X-unique material that included the Paf locus. This hypothesis was validated by Southern analysis using an X PAR boundary probe to show that Y* has an X PAR boundary. Thus the Y* PAR has resulted from an end to end fusion of an X and a Y PAR. Furthermore, it was shown that in conjunction with this PAR-PAR fusion, there has been deletion of both copies of the distally located pseudoautosomal gene Steroid sulfatase (Sts).
P S Burgoyne; S K Mahadevaiah; J Perry; S J Palmer; A Ashworth
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytogenetics and cell genetics     Volume:  80     ISSN:  0301-0171     ISO Abbreviation:  Cytogenet. Cell Genet.     Publication Date:  1998  
Date Detail:
Created Date:  1998-08-21     Completed Date:  1998-08-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0367735     Medline TA:  Cytogenet Cell Genet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  37-40     Citation Subset:  IM    
Laboratory of Developmental Genetics, National Institute for Medical Research, Mill Hill, London, UK.
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MeSH Terms
Crossing Over, Genetic
Gene Rearrangement*
Mice, Inbred C3H
X Chromosome*
Y Chromosome*

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