Document Detail


Y not a dead end: epistatic interactions between Y-linked regulatory polymorphisms and genetic background affect global gene expression in Drosophila melanogaster.
MedLine Citation:
PMID:  20551438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Y chromosome, inherited without meiotic recombination from father to son, carries relatively few genes in most species. This is consistent with predictions from evolutionary theory that nonrecombining chromosomes lack variation and degenerate rapidly. However, recent work has suggested a dynamic role for the Y chromosome in gene regulation, a finding with important implications for spermatogenesis and male fitness. We studied Y chromosomes from two populations of Drosophila melanogaster that had previously been shown to have major effects on the thermal tolerance of spermatogenesis. We show that these Y chromosomes differentially modify the expression of hundreds of autosomal and X-linked genes. Genes showing Y-linked regulatory variation (YRV) also show an association with immune response and pheromone detection. Indeed, genes located proximal to the euchromatin-heterochromatin boundary of the X chromosome appear particularly responsive to Y-linked variation, including a substantial number of odorant-binding genes. Furthermore, the data show significant regulatory interactions between the Y chromosome and the genetic background of autosomes and X chromosome. Altogether, our findings support the view that interpopulation, Y-linked regulatory polymorphisms can differentially modulate the expression of many genes important to male fitness, and they also point to complex interactions between the Y chromosome and genetic background affecting global gene expression.
Authors:
Pan-Pan Jiang; Daniel L Hartl; Bernardo Lemos
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-06-15
Journal Detail:
Title:  Genetics     Volume:  186     ISSN:  1943-2631     ISO Abbreviation:  Genetics     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-21     Completed Date:  2011-01-05     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-18     Citation Subset:  IM    
Affiliation:
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA. pjiang@oeb.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Drosophila melanogaster / genetics*
Epistasis, Genetic / genetics*
Female
Gene Expression Profiling*
Gene Order / genetics
Genomics
Inbreeding
Male
Multigene Family / genetics
Polymorphism, Genetic / genetics*
Tropical Climate
X Chromosome / genetics
Y Chromosome / genetics*
Grant Support
ID/Acronym/Agency:
GM084236/GM/NIGMS NIH HHS
Comments/Corrections

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