Document Detail

Ximelagatran for prevention and treatment of venous thromboembolism.
MedLine Citation:
PMID:  15214359     Owner:  HSR     Status:  MEDLINE    
Ximelagatran (Exanta (TM)) is the first oral agent in a new class of anticoagulants called direct thrombin inhibitors. Most of the available evidence regarding venous thromboembolism is from studies focusing on its prevention after major orthopedic surgery. Ximelagatran's efficacy is comparable to that of warfarin and low-molecular-weight heparin in this setting. The rates of bleeding complications for ximelagatran and its comparators were not statistically different. The elevation of liver enzymes was observed in longer term trials.
Lisa Kwok; Michel Boucher
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Issues in emerging health technologies     Volume:  -     ISSN:  1488-6316     ISO Abbreviation:  Issues Emerg Health Technol     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-23     Completed Date:  2004-07-07     Revised Date:  2010-01-22    
Medline Journal Info:
Nlm Unique ID:  100886782     Medline TA:  Issues Emerg Health Technol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  T    
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MeSH Terms
Administration, Oral
Anticoagulants / adverse effects,  pharmacology,  therapeutic use*
Azetidines / adverse effects,  pharmacology,  therapeutic use*
Clinical Trials as Topic
Dose-Response Relationship, Drug
Drug Approval
Evidence-Based Medicine
Heparin, Low-Molecular-Weight / adverse effects,  pharmacology,  therapeutic use*
Orthopedic Procedures / adverse effects
Randomized Controlled Trials as Topic
Risk Factors
Venous Thrombosis / drug therapy*,  prevention & control*
Reg. No./Substance:
0/Anticoagulants; 0/Azetidines; 0/Heparin, Low-Molecular-Weight; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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