| Xg expression in Ewing's sarcoma is of prognostic value and contributes to tumor invasiveness. | |
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MedLine Citation:
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PMID: 20388798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ewing's sarcoma (EWS) is an aggressive tumor of children and young adults that requires intensive treatment. The search for new prognostic factors is very important to choose the most appropriate therapy and to better understand the biology of the disease for the development of new therapeutic tools. We found that Xg, a thus far poorly described molecule and member of the CD99 family, is expressed in EWS cell lines and EWS primary tumors. Immunohistochemical analysis confirmed the expression of Xg in 24% of patients. We found that Xg expression in EWS defines a subgroup of patients with worse prognosis compared with those with Xg-negative localized tumors, indicating a clinical relevance of Xg expression in EWS. Forced expression of Xg in an EWS cell line upregulated cell migration and invasion in vitro. Furthermore, knockdown of Xg expression with specific short hairpin RNA significantly reduced migration and invasion of EWS cells. Consistent with these data, in vivo xenotransplant studies in nude mice revealed that Xg expression increased the incidence and the number of metastases of EWS cells. Thus, Xg expression is associated with lower overall survival in EWS patients with localized tumors and is implicated in metastasis. |
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Authors:
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Oph?lie Meynet; Katia Scotlandi; Emmanuelle Pradelli; Maria C Manara; Mario P Colombo; Heidy Schmid-Antomarchi; Piero Picci; Alain Bernard; Ghislaine Bernard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-13 |
Journal Detail:
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Title: Cancer research Volume: 70 ISSN: 1538-7445 ISO Abbreviation: Cancer Res. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-30 Completed Date: 2010-05-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 3730-8 Citation Subset: IM |
Copyright Information:
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(c)2010 AACR. |
Affiliation:
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Institut National de la Sante et de la Recherche Medicale UMR 576 and CHU Nice, Hopital de l'Archet, Laboratoire d'Immunologie, Nice, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Animals Blood Group Antigens / biosynthesis* Bone Neoplasms / immunology, metabolism, pathology Cell Adhesion Molecules / biosynthesis* Cell Line, Tumor Cell Movement / physiology Child Female Humans Lung Neoplasms / immunology, metabolism, secondary Male Mice Mice, Nude Neoplasm Invasiveness Osteosarcoma / immunology, metabolism, pathology Prognosis Sarcoma, Ewing's / immunology, metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Blood Group Antigens; 0/Cell Adhesion Molecules; 0/XG protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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