Document Detail


Xeroderma pigmentosum skin: an immune privilege site for tumor development.
MedLine Citation:
PMID:  19719835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A unique feature of the skin immune system is its proximity to cells continuously exposed to sun rays, as it is located in the interface between the body and the environment. In this study, we aimed to determine the impact of DNA damaged keratinocytes on the expression of apoptotic-related molecules, in T-cells of the inflammatory component of the tumor environment. Immunohistochemistry was performed on tissue sections derived from skin biopsies of basal cell carcinomas (BCCs) of xeroderma pigmentosum (XP) patients, non-XP patients and nevoid basal cell carcinoma syndrome (NBCCS) patients, using antibodies against B-cell lymphoma/leukemia-2 (Bcl-2), Bcl-2 associated X protein (Bax), CD95, CD3, CD8 and CD56. Our results showed significantly lower levels of expression of the antiapoptotic Bcl-2 molecule, in XP, in comparison with non-XP and NBCCS T-lymphocytes, leading to the highest Bax/Bcl-2 ratio for XP T-cells. For the CD95 receptor expression levels, there were significant differences among T-cells of the three patient subgroups as well. The higher propensity of XP T-cells to undergo apoptosis may have evolved in individual XP patients, apparently during the course of their disease, to maintain a special skin as an immune privilege site for tumors' development.
Authors:
Kalthoum Abid; Faouzi El Mezni; Mohamed Ridha Kamoun; Becima Fazaa; Rachida Zermani; Chokri Hadouchi; Kamel Hamzaoui
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Publication Detail:
Type:  Journal Article     Date:  2009-08-27
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  37     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  452-9     Citation Subset:  IM    
Affiliation:
Immuno-Histology Laboratory, Medicine University of Tunis, Tunisia. abid_kalthoum@yahoo.fr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antigens, CD / metabolism
Apoptosis / immunology
Basal Cell Nevus Syndrome / immunology,  metabolism
Carcinoma, Basal Cell / immunology,  metabolism*
Cell Survival / genetics
Child
Female
Humans
Immunohistochemistry
Keratinocytes / immunology,  metabolism*,  pathology
Male
Middle Aged
Proto-Oncogene Proteins c-bcl-2 / metabolism
Skin / immunology,  metabolism*,  pathology
Skin Neoplasms / immunology,  metabolism*,  pathology
Xeroderma Pigmentosum / immunology,  metabolism*,  pathology
bcl-2-Associated X Protein / metabolism
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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