Document Detail


Xenotransplantation--will it bring the solution to organ shortage?
MedLine Citation:
PMID:  15478879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Xenotransplantation, the transplantation of organs, tissues and cells from animals, preferably pig-to-man, might be considered to become the transplantation of the future. Organs from domestic animals are available in unlimited numbers for xenogeneic transplantation and could swiftly solve the problem of organ shortages. Domestic animals of about the same size as human beings would be ideal organ sources. By selective breeding the anatomical and some physiological characteristics of these animals could be at least partly adapted to match the human body. However, the immunological mechanisms and the antigenicity of cells and their surface structures will remain obstinately unaltered. The only hope is that wide-reaching transgenic manipulation of animals, will soon achieve great changes in immunological and physiological circumstances.
Authors:
C Hammer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of transplantation : quarterly of the Polish Transplantation Society     Volume:  9     ISSN:  1425-9524     ISO Abbreviation:  Ann. Transplant.     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-13     Completed Date:  2004-11-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9802544     Medline TA:  Ann Transplant     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  7-10     Citation Subset:  IM    
Affiliation:
Institute for Surgical Research Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany. hammer@icf.med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Genetic Techniques
Graft Rejection / prevention & control
Health Services Accessibility*
Humans
Immunosuppression
Swine
Tissue and Organ Procurement*
Transplantation, Heterologous*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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