Document Detail

Xenotransplantation of embryonic precursors of human myogenesis for the correction of dystrophinopathy in mice with hereditary muscular dystrophy.
MedLine Citation:
PMID:  14534620     Owner:  NLM     Status:  MEDLINE    
Human embryonic myogenic precursors were transplanted into muscles of mdx mice with hereditary dystrophin-deficient muscular dystrophy. Transplantation induced the synthesis of human dystrophin. The number of dystrophin-positive fibers progressively decreased, however, some of them were preserved even 5 months after transplantation. Our results indicate that xenogeneic transplantation of embryonic myogenic precursors compensates the genetic defect in dystrophin-deficient mice.
V N Yarygin; G T Sukhikh; V F Sitnikov; M A Stenina; A B Kuznetsov; R A Poltavtseva; L I Krivov; D A Voevodin; V I Savchuk; A V Revishchin; L I Korochkin; M A Aleksandrova
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  136     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-10-09     Completed Date:  2004-10-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  88-92     Citation Subset:  IM    
Russian State Medical University, Moscow.
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MeSH Terms
Cell Transplantation
DNA / metabolism
Disease Models, Animal
Dystrophin / genetics,  metabolism
Embryo, Mammalian / cytology*
Mice, Inbred mdx
Muscles / cytology*
Muscular Dystrophies / genetics,  pathology*
Muscular Dystrophy, Animal / genetics,  pathology*
Polymerase Chain Reaction
Time Factors
Transplantation, Heterologous
Reg. No./Substance:
0/Dystrophin; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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