Document Detail

Xenon washout during in-vitro extracorporeal circulation using different oxygenators.
MedLine Citation:
PMID:  12455738     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Xenon anesthesia is known to have no adverse influence on myocardial contractility and cardiocirculatory function even in cardiac compromised patients. To make use of this advantages for cardiac surgery patients undergoing extracorporeal circulation (ECC) it must be known if oxygenators are diffusible for xenon in order to avoid losses of the very expensive noble gas. METHODS: Xenon saturated blood was recirculated in an in-vitro ECC. In 8 experiments four common oxygenators were investigated using continuous mass spectrometry at the exhaust port to measure xenon concentrations in the exspired gas. RESULTS: Xenon concentrations at the exhaust port of the oxygenator increased during filling the oxygenator with blood. Peak level was detected within one minute after onset of ECC. No xenon could be measured two minutes after onset of ECC. CONCLUSIONS: Using common oxygenators xenon is eliminated during ECC and lost into the atmosphere. To maintain anesthesia during ECC continuous xenon application would be necessary to compensate these losses. Due to its high price it would be too expensive to continue xenon anesthesia during ECC. Therefore it is not practicable to use the today's oxygenators and ECC equipment in xenon anesthesia.
Uwe Schirmer; Helmut Reinelt; Matthias Erber; Michael Schmidt; Thomas Marx
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical monitoring and computing     Volume:  17     ISSN:  1387-1307     ISO Abbreviation:  J Clin Monit Comput     Publication Date:    2002 Apr-May
Date Detail:
Created Date:  2002-11-28     Completed Date:  2003-05-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9806357     Medline TA:  J Clin Monit Comput     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  211-5     Citation Subset:  IM    
Department of Cardiac Anesthesia , University of Ulm, D-89075 Ulm, Germany.
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MeSH Terms
Cardiac Surgical Procedures*
Extracorporeal Circulation*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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