| Xenon and isoflurane improved biventricular function during right ventricular ischemia and reperfusion. | |
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MedLine Citation:
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PMID: 19839950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although anesthetics have some cardioprotective properties, these benefits are often counterbalanced by their negative inotropic effects. Xenon, on the other hand, does not influence myocardial contractility. Thus, xenon may be a superior treatment for the maintenance of global hemodynamics, especially during right ventricular ischemia, which is generally characterized by a high acute complication rate. METHODS: The effects of 70 vol% xenon and 0.9 vol% isoflurane on biventricular function were assessed in a porcine model (n=36) using the conductance catheter technique, and the expression of the type B natriuretic peptide (BNP) gene was measured. The animals underwent 90 min of right ventricular ischemia followed by 120 min of reperfusion. A barbiturate-anesthetized group was included as a control. RESULTS: Cardiac output was compromised in unprotected animals during ischemia by 33+/-18% and during reperfusion by 53+/-17%. This was mainly due to impaired contractility in the left ventricle (LV) and increased stiffness. Isoflurane attenuated the increase in stiffness and resulted in a higher preload. In contrast, xenon increased the right ventricular afterload, which was compensated by an increase in contractility. Its effects on diastolic function were less pronounced. Upregulation of BNP mRNA expression was impeded in the remote area of the LV by both isoflurane and xenon. CONCLUSIONS: Xenon and isoflurane demonstrated equipotent effects in preventing the hemodynamic compromise that is induced by right ventricular ischemia and reperfusion, although they acted through somewhat differential inotropic and vasodilatory effects. |
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Authors:
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M Hein; A B Roehl; J H Baumert; C Bleilevens; S Fischer; P Steendijk; R Rossaint |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-15 |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 54 ISSN: 1399-6576 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: England |
Other Details:
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Languages: eng Pagination: 470-8 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, University Hospital of Aachen, Aachen, Germany. mhein@ukaachen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Inhalation
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therapeutic use* Animals Cardiac Output / drug effects, physiology Data Interpretation, Statistical Isoflurane / pharmacology* Myocardial Contraction / drug effects, physiology Myocardial Reperfusion Injury / physiopathology*, prevention & control* Natriuretic Peptide, Brain / blood, genetics RNA, Messenger / biosynthesis, genetics Reverse Transcriptase Polymerase Chain Reaction Swine Ventricular Dysfunction, Right / drug therapy*, physiopathology Ventricular Function, Left / physiology Xenon / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/RNA, Messenger; 114471-18-0/Natriuretic Peptide, Brain; 26675-46-7/Isoflurane; 7440-63-3/Xenon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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