Document Detail

Xenon improves recovery from myocardial stunning in chronically instrumented dogs.
MedLine Citation:
PMID:  15333388     Owner:  NLM     Status:  MEDLINE    
In this study we tested the hypothesis that inhalational administration of xenon improves recovery from myocardial stunning. Ten dogs were chronically instrumented for measurement of heart rate; left atrial, aortic, and left ventricular pressure; coronary blood-flow velocity; and myocardial wall-thickening fraction. Regional myocardial blood flow was determined with fluorescent microspheres. Catecholamine plasma levels were measured by high-performance liquid chromatography. An occluder around the left anterior descending artery (LAD) allowed the induction of a reversible LAD ischemia. Animals underwent 2 experimental conditions in a randomized crossover fashion on separate days: (a) 10 min of LAD occlusion under fentanyl (25 microg. kg(-1). h(-1)) and midazolam (0.6 mg. kg(-1). h(-1)) (control) and (b) a second ischemic episode under the same basal anesthesia with concomitant inhalational administration of 75 +/- 1 vol% xenon (intervention). Anesthesia was induced 35 min before LAD occlusion and was discontinued after 20 min of reperfusion. Dogs receiving xenon showed a significantly better recovery of wall-thickening fraction up to 12 h after ischemia. The increase in plasma epinephrine during emergence from anesthesia and in the early reperfusion period was significantly attenuated in the xenon group. There were no differences between groups concerning global hemodynamics, blood-flow velocity, or regional myocardial blood flow. In conclusion, inhalational administration of 75 vol% xenon improves recovery from myocardial stunning in chronically instrumented dogs under fentanyl/midazolam anesthesia.
Maike A Grosse Hartlage; Elmar Berendes; Hugo Van Aken; Manfred Fobker; Marc Theisen; Thomas P Weber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  99     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-30     Completed Date:  2004-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  655-64, table of contents     Citation Subset:  AIM; IM    
Universitätsklinikum Münster, Klinik und Poliklinik für Anästhesiologie und Operative Intensivmedizin, Albert-Schweitzer-Strasse 33, 48149 Münster, Germany.
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MeSH Terms
Blood Pressure / drug effects
Coronary Circulation / drug effects
Epinephrine / blood
Heart Rate / drug effects
Myocardial Stunning / drug therapy*,  physiopathology
Ventricular Function, Left / drug effects
Xenon / pharmacology,  therapeutic use*
Reg. No./Substance:
51-43-4/Epinephrine; 7440-63-3/Xenon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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