Document Detail


Xenon does not trigger malignant hyperthermia in susceptible swine.
MedLine Citation:
PMID:  10519508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Xenon is a noble gas with anesthetic properties currently under investigation for use in humans. This study was performed to evaluate whether xenon may trigger malignant hyperthermia in susceptible swine. METHODS: Nine malignant hyperthermia-sensitive swine (Pietrain) were initially anesthetized with pentobarbital and then ventilated with 70% xenon in oxygen for 2 h. Heart rate, mean arterial pressure, cardiac output, body temperature, arterial and mixed-venous blood gases, and plasma catecholamine and lactate levels were measured every 10 min both during xenon-oxygen ventilation and after a 30-min xenon washout phase followed by subsequent administration of halothane (1% inspired) and succinylcholine (3 mg/kg intravenous). During the investigation, no malignant hyperthermia-specific therapy was instituted. RESULTS: Xenon exposure did not induce any changes in metabolic and hemodynamic parameters nor elevations of the plasma catecholamine levels indicative for an episode of malignant hyperthermia. By contrast, in all animals, within 20 min after the administration of halothane and succinylcholine, fulminant and fatal malignant hyperthermia episodes were initiated. CONCLUSIONS: The authors conclude that xenon does not trigger malignant hyperthermia in susceptible swine.
Authors:
G Froeba; T Marx; J Pazhur; C Baur; S Baeder; E Calzia; H M Eichinger; P Radermacher; M Georgieff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  91     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-10-27     Completed Date:  1999-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1047-52     Citation Subset:  AIM; IM    
Affiliation:
Universitätsklinik für Anästhesiologie, Universität Ulm, Germany. gebhard.froeba@medizin.uni-ulm.de
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Substitution
Anesthesia, General / adverse effects*
Anesthetics, Inhalation / adverse effects*
Animals
Arginine / genetics
Blood Pressure / drug effects
Cardiac Output / drug effects
Cysteine / genetics
Genetic Predisposition to Disease*
Halothane / adverse effects
Heart Rate / drug effects
Homozygote
Malignant Hyperthermia / etiology,  genetics*
Mutation
Ryanodine Receptor Calcium Release Channel / genetics
Swine
Xenon / adverse effects*
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Ryanodine Receptor Calcium Release Channel; 151-67-7/Halothane; 52-90-4/Cysteine; 74-79-3/Arginine; 7440-63-3/Xenon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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