| Xenon does not trigger malignant hyperthermia in susceptible swine. | |
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MedLine Citation:
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PMID: 10519508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Xenon is a noble gas with anesthetic properties currently under investigation for use in humans. This study was performed to evaluate whether xenon may trigger malignant hyperthermia in susceptible swine. METHODS: Nine malignant hyperthermia-sensitive swine (Pietrain) were initially anesthetized with pentobarbital and then ventilated with 70% xenon in oxygen for 2 h. Heart rate, mean arterial pressure, cardiac output, body temperature, arterial and mixed-venous blood gases, and plasma catecholamine and lactate levels were measured every 10 min both during xenon-oxygen ventilation and after a 30-min xenon washout phase followed by subsequent administration of halothane (1% inspired) and succinylcholine (3 mg/kg intravenous). During the investigation, no malignant hyperthermia-specific therapy was instituted. RESULTS: Xenon exposure did not induce any changes in metabolic and hemodynamic parameters nor elevations of the plasma catecholamine levels indicative for an episode of malignant hyperthermia. By contrast, in all animals, within 20 min after the administration of halothane and succinylcholine, fulminant and fatal malignant hyperthermia episodes were initiated. CONCLUSIONS: The authors conclude that xenon does not trigger malignant hyperthermia in susceptible swine. |
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Authors:
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G Froeba; T Marx; J Pazhur; C Baur; S Baeder; E Calzia; H M Eichinger; P Radermacher; M Georgieff |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesiology Volume: 91 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-10-27 Completed Date: 1999-10-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1047-52 Citation Subset: AIM; IM |
Affiliation:
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Universitätsklinik für Anästhesiologie, Universität Ulm, Germany. gebhard.froeba@medizin.uni-ulm.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Substitution Anesthesia, General / adverse effects* Anesthetics, Inhalation / adverse effects* Animals Arginine / genetics Blood Pressure / drug effects Cardiac Output / drug effects Cysteine / genetics Genetic Predisposition to Disease* Halothane / adverse effects Heart Rate / drug effects Homozygote Malignant Hyperthermia / etiology, genetics* Mutation Ryanodine Receptor Calcium Release Channel / genetics Swine Xenon / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Ryanodine Receptor Calcium Release Channel; 151-67-7/Halothane; 52-90-4/Cysteine; 74-79-3/Arginine; 7440-63-3/Xenon |
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