Document Detail


Xenon and Isoflurane Reduce Left Ventricular Remodeling after Myocardial Infarction in the Rat.
MedLine Citation:
PMID:  23364599     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND:: Xenon and isoflurane are known to have cardioprotective properties. We tested the hypothesis that these anesthetics positively influence myocardial remodeling 28 days after experimental perioperative myocardial infarction and compared their effects. METHODS:: A total of 60 male Sprague-Dawley rats were subjected to 60 min of coronary artery occlusion and 120 min of reperfusion. Prior to ischemia, the animals were randomized for the different narcotic regimes (0.6 vol% isoflurane, 70 vol% xenon, or intraperitoneal injection of s-ketamine). Acute injury was quantified by echocardiography and troponin I. After 4 weeks, left ventricular function was assessed by conductance catheter to quantify hemodynamic compromise. Cardiac remodeling was characterized by quantification of dilatation, hypertrophy, fibrosis, capillary density, apoptosis, and expression of fetal genes (α/β myosin heavy chains, α-skeletal actin, periostin, and sarco/endoplasmic reticulum Ca-ATPase). RESULTS:: Whereas xenon and isoflurane impeded the acute effects of ischemia-reperfusion on hemodynamics and myocardial injury at a comparable level, differences were found after 4 weeks. Xenon in contrast to isoflurane or ketamine anesthetized animals demonstrated a lower remodeling index (0.7 ± 0.1 vs. 0.9 ± 0.3 and 1.0 ± 0.3 g/ml), better ejection fraction (62 ± 9 vs. 49 ± 7 and 35 ± 6%), and reduced expression of β-myosin heavy chain and periostin. The effects on hypertrophy, fibrosis, capillary density, and apoptosis were comparable. CONCLUSIONS:: Compared to isoflurane and s-ketamine, xenon limited progressive adverse cardiac remodeling and contractile dysfunction 28 days after perioperative myocardial infarction.
Authors:
Anna B Roehl; Sandra Funcke; Michael M Becker; Andreas Goetzenich; Christian Bleilevens; Rolf Rossaint; Paul Steendijk; Marc Hein
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-29
Journal Detail:
Title:  Anesthesiology     Volume:  -     ISSN:  1528-1175     ISO Abbreviation:  Anesthesiology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
* Anesthetist, Department of Anesthesiology, University Hospital Aachen, Aachen, Germany. † Resident, Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ‡ Cardiologist, Department of Cardiology, University Hospital Aachen, Aachen, Germany. § Anesthetist, Department of Cardiac Surgery, University Hospital Aachen, Aachen, Germany. ║ Research Assistant, Department of Anesthesiology, University Hospital Aachen, Aachen, Germany. # Professor, Department of Anesthesiology, University Hospital Aachen, Aachen, Germany. ** Associate Professor, Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands.
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