Document Detail

Xenoderm versus 1% silver sulfadiazine in partial-thickness burns.
MedLine Citation:
PMID:  19892627     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this clinical trial was to evaluate the effectiveness of using lyophilised porcine skin (Xenoderm) compared with 1% silver sulfadiazine (SSD) in partial-thickness burns with regard to wound infection, length of hospital stay, number of dressings and doses of analgesics used (oral and injection).
METHODS: A total of 78 burns patients were included in this randomised study; their burns were caused by scalds or flames. They had second degree burns and had a burn area of 1060% of total body surface area (TBSA). Thirty-seven patients were treated with daily washing, followed by topical application of SSD dressing (the SSD group) and 39 with a biological dressing, i.e. Xenoderm (the Xenoderm group). The differences were evaluated using unpaired Student's t-test, Mann-Whitney U test and Chi-square test.
RESULTS: There were no significant differences between the two groups with respect to age, gender, TBSA, cause of burn, and thickness of the burn or burn site. But there were significant differences regarding degree of wound infection, length of hospital stay, number of used dressings and given doses of analgesics.
CONCLUSION: Xenoderm seems to be more effective than SSD dressing in terms of pain control, degree of wound infection, used wound dressings and length of hospital stay for partial-thickness burns. Prospective randomised studies are now necessary to compare possible reductions in the use of split thickness skin grafts and re-epithelialisation times.
Seyed Nejat Hosseini; Anayatollah Karimian; Seyed Nouraddin Mousavinasab; Haleh Rahmanpour; Mehdi Yamini; Shokoufeh Hosseini Zahmatkesh
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Asian journal of surgery / Asian Surgical Association     Volume:  32     ISSN:  0219-3108     ISO Abbreviation:  Asian J Surg     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-06     Completed Date:  2010-02-12     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  8900600     Medline TA:  Asian J Surg     Country:  China    
Other Details:
Languages:  eng     Pagination:  234-9     Citation Subset:  IM    
Burns Department, Ayatollah-Mousavi Hospital, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
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MeSH Terms
Anti-Infective Agents, Local / administration & dosage*
Biological Dressings*
Burns / therapy*
Child, Preschool
Middle Aged
Prospective Studies
Silver Sulfadiazine / administration & dosage*
Reg. No./Substance:
0/Anti-Infective Agents, Local; 22199-08-2/Silver Sulfadiazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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