| Xenobiotic phenols in early pregnancy amniotic fluid. | |
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MedLine Citation:
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PMID: 16112541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We found detectable levels of three phytoestrogens (enterolactone, daidzein and genistein) and bisphenol A (BPA) in 21 residual amniotic fluid specimens that were collected before 20 weeks gestation. Samples were obtained by amniocentesis from women who were referred to the Mount Sinai Medical center because of advanced maternal age. Phytoestrogens were present in higher concentrations than BPA. Enterolactone was detected at the highest concentration (median 95.9 microg/L), followed by daidzein and genistein (9.5 and 1.4 microg/L, respectively). BPA was present at very low concentrations (10%>LOD of 0.5 microg/L). The relative concentration of the chemicals measured in amniotic fluid were identical to those in urine reported by other studies, i.e. enterolactone>daidzein>genistein>>BPA. Amniotic fluid is a source of fetal exposure to polar xenobiotics that come from the mother. |
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Authors:
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Stephanie M Engel; Brynn Levy; Zhisong Liu; Dana Kaplan; Mary S Wolff |
Publication Detail:
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Type: Journal Article Date: 2005-08-19 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 21 ISSN: 0890-6238 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-09 Completed Date: 2006-03-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 110-2 Citation Subset: IM |
Affiliation:
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Department of Community and Preventive Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1043, New York, NY 10029, USA. Stephanie.Engel@mssm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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4-Butyrolactone
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analogs & derivatives*,
analysis Amniotic Fluid / chemistry* Estrogens, Non-Steroidal / analysis Female Genistein / analysis* Humans Isoflavones / analysis* Lignans / analysis* Maternal Exposure Maternal-Fetal Exchange Phenols / analysis* Phytoestrogens / analysis Pregnancy Xenobiotics / analysis |
| Chemical | |
Reg. No./Substance:
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0/Estrogens, Non-Steroidal; 0/Isoflavones; 0/Lignans; 0/Phenols; 0/Phytoestrogens; 0/Xenobiotics; 446-72-0/Genistein; 486-66-8/daidzein; 76543-15-2/2,3-bis(3'-hydroxybenzyl)butyrolactone; 80-05-7/bisphenol A; 96-48-0/4-Butyrolactone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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