Document Detail

Xenobiotic phenols in early pregnancy amniotic fluid.
MedLine Citation:
PMID:  16112541     Owner:  NLM     Status:  MEDLINE    
We found detectable levels of three phytoestrogens (enterolactone, daidzein and genistein) and bisphenol A (BPA) in 21 residual amniotic fluid specimens that were collected before 20 weeks gestation. Samples were obtained by amniocentesis from women who were referred to the Mount Sinai Medical center because of advanced maternal age. Phytoestrogens were present in higher concentrations than BPA. Enterolactone was detected at the highest concentration (median 95.9 microg/L), followed by daidzein and genistein (9.5 and 1.4 microg/L, respectively). BPA was present at very low concentrations (10%>LOD of 0.5 microg/L). The relative concentration of the chemicals measured in amniotic fluid were identical to those in urine reported by other studies, i.e. enterolactone>daidzein>genistein>>BPA. Amniotic fluid is a source of fetal exposure to polar xenobiotics that come from the mother.
Stephanie M Engel; Brynn Levy; Zhisong Liu; Dana Kaplan; Mary S Wolff
Publication Detail:
Type:  Journal Article     Date:  2005-08-19
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  21     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-09     Completed Date:  2006-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  110-2     Citation Subset:  IM    
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1043, New York, NY 10029, USA.
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MeSH Terms
4-Butyrolactone / analogs & derivatives*,  analysis
Amniotic Fluid / chemistry*
Estrogens, Non-Steroidal / analysis
Genistein / analysis*
Isoflavones / analysis*
Lignans / analysis*
Maternal Exposure
Maternal-Fetal Exchange
Phenols / analysis*
Phytoestrogens / analysis
Xenobiotics / analysis
Reg. No./Substance:
0/Estrogens, Non-Steroidal; 0/Isoflavones; 0/Lignans; 0/Phenols; 0/Phytoestrogens; 0/Xenobiotics; 446-72-0/Genistein; 486-66-8/daidzein; 76543-15-2/2,3-bis(3'-hydroxybenzyl)butyrolactone; 80-05-7/bisphenol A; 96-48-0/4-Butyrolactone

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