Document Detail


Xenobiotic bioconversion in human epidermis models.
MedLine Citation:
PMID:  12948006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is a great need for alternative experimental methods for measuring percutaneous xenobiotic biotransformation. Animal testing and excised human skin studies have been the historical standards for confirmation of therapeutic and toxic effects that occur in the skin as a result of drug and other chemical metabolism. Human skin epidermal bioequivalents have become progressively more used for these types of pharmacological/toxicological studies in recent years. These epidermal models have been used in the form of cell culture, tissue sheets, and highly differentiated epidermal and epidermal/dermal systems. This review highlights the existing published data on the utility of these skin bioequivalent models for various types of metabolism and toxicology studies that should be of interest to the dermatopharmaceutical scientist.
Authors:
Audra L Stinchcomb
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Pharmaceutical research     Volume:  20     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-01     Completed Date:  2004-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1113-8     Citation Subset:  IM    
Affiliation:
Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Lexington, Kentucky 40536-0082, USA. astin2@email.uky.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Biotransformation
Cells, Cultured
Epidermis / metabolism*
Humans
Models, Biological
Xenobiotics / administration & dosage,  metabolism,  pharmacokinetics*
Grant Support
ID/Acronym/Agency:
AA13853/AA/NIAAA NIH HHS; DA13425/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Xenobiotics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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