| Xenobiotic particle exposure and microvascular endpoints: a call to arms. | |
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MedLine Citation:
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PMID: 21951337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Xenobiotic particles can be considered in two genres: air pollution particulate matter and engineered nanoparticles. Particle exposures can occur in the greater environment, the workplace, and our homes. The majority of research in this field has, justifiably, focused on pulmonary reactions and outcomes. More recent investigations indicate that cardiovascular effects are capable of correlating with established mortality and morbidity epidemiological data following particle exposures. While the preliminary and general cardiovascular toxicology has been defined, the mechanisms behind these effects, specifically within the microcirculation, are largely unexplored. Therefore, the purpose of this review is several fold: first, a historical background on toxicological aspects of particle research is presented. Second, essential definitions, terminology, and techniques that may be unfamiliar to the microvascular scientist will be discussed. Third, the most current concepts and hypotheses driving cardiovascular research in this field will be reviewed. Lastly, potential future directions for the microvascular scientist will be suggested. Collectively speaking, microvascular research in the particle exposure field represents far more than a "niche." The immediate demand for basic, translational, and clinical studies is high and diverse. Microvascular scientists at all career stages are strongly encouraged to expand their research interests to include investigations associated with particle exposures. |
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Authors:
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Phoebe A Stapleton; Valerie C Minarchick; Michael McCawley; Travis L Knuckles; Timothy R Nurkiewicz |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: 19 ISSN: 1549-8719 ISO Abbreviation: Microcirculation Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-14 Completed Date: 2012-06-11 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: United States |
Other Details:
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Languages: eng Pagination: 126-42 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons Ltd. |
Affiliation:
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Center for Cardiovascular and Respiratory Sciences, WV 26506-9105, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular Diseases / chemically induced*, mortality, physiopathology* Humans Microcirculation / drug effects* Particulate Matter / adverse effects* Xenobiotics / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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R01 ES015022-05/ES/NIEHS NIH HHS; R01-ES015022/ES/NIEHS NIH HHS; RC1 ES018274-02/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Particulate Matter; 0/Xenobiotics |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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