| Xenobiotic- and jasmonic acid-inducible signal transduction pathways have become interdependent at the Arabidopsis CYP81D11 promoter. | |
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MedLine Citation:
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PMID: 22452854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plants modify harmful substances through an inducible detoxification system. In Arabidopsis (Arabidopsis thaliana), chemical induction of the cytochrome P450 gene CYP81D11 and other genes linked to the detoxification program depends on class II TGA transcription factors. CYP81D11 expression is also induced by the phytohormone jasmonic acid (JA) through the established pathway requiring the JA receptor CORONATINE INSENSITIVE1 (COI1) and the JA-regulated transcription factor MYC2. Here, we report that the xenobiotic- and the JA-dependent signal cascades have become interdependent at the CYP81D11 promoter. On the one hand, MYC2 can only activate the expression of CYP81D11 when both the MYC2- and the TGA-binding sites are present in the promoter. On the other hand, the xenobiotic-regulated class II TGA transcription factors can only mediate maximal promoter activity if TGA and MYC2 binding motifs, MYC2, and the JA-isoleucine biosynthesis enzymes DDE2/AOS and JAR1 are functional. Since JA levels and degradation of JAZ1, a repressor of the JA response, are not affected by reactive chemicals, we hypothesize that basal JA signaling amplifies the response to chemical stress. Remarkably, stress-induced expression levels were 3-fold lower in coi1 than in the JA biosynthesis mutant dde2-2, [corrected] revealing that COI1 can contribute to the activation of the promoter in the absence of JA. Moreover, we show that deletion of the MYC2 binding motifs abolishes the JA responsiveness of the promoter but not the responsiveness to COI1. These findings suggest that yet unknown cis-element(s) can mediate COI1-dependent transcriptional activation in the absence of JA. |
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Authors:
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Julia Köster; Corinna Thurow; Kerstin Kruse; Alexander Meier; Tim Iven; Ivo Feussner; Christiane Gatz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-03-27 |
Journal Detail:
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Title: Plant physiology Volume: 159 ISSN: 1532-2548 ISO Abbreviation: Plant Physiol. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-04 Completed Date: 2012-08-23 Revised Date: 2013-05-02 |
Medline Journal Info:
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Nlm Unique ID: 0401224 Medline TA: Plant Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 391-402 Citation Subset: IM |
Affiliation:
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Albrecht-von-Haller-Institut für Pflanzenwissenschaften, Georg-August-Universität Göttingen, D-37077 Gottingen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Motifs Arabidopsis / genetics*, metabolism Arabidopsis Proteins / genetics, metabolism Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics, metabolism Benzoxazoles / pharmacology Cyclopentanes / metabolism*, pharmacology Cytochrome P-450 Enzyme System / genetics*, metabolism Gene Expression Regulation, Plant Nucleotidyltransferases / genetics, metabolism Oxylipins / metabolism*, pharmacology Plasmids / genetics, metabolism Promoter Regions, Genetic* Regulatory Sequences, Nucleic Acid Signal Transduction / drug effects* Transcriptional Activation Transformation, Genetic Triiodobenzoic Acids / pharmacology Xenobiotics / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Arabidopsis Proteins; 0/Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0/Benzoxazoles; 0/COI1 protein, Arabidopsis; 0/Cyclopentanes; 0/MYC2 protein, Arabidopsis; 0/Oxylipins; 0/Triiodobenzoic Acids; 0/Xenobiotics; 59-49-4/benzoxazolone; 6RI5N05OWW/jasmonic acid; 88-82-4/2,3,5-triiodobenzoic acid; 9035-51-2/Cytochrome P-450 Enzyme System; EC 2.7.7.-/JAR1 protein, Arabidopsis; EC 2.7.7.-/Nucleotidyltransferases |
| Comments/Corrections | |
Erratum In:
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Plant Physiol. 2012 Jul;159(3):1292 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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