Document Detail

Xanthomatous hypophysitis mimicking a pituitary adenoma: case report and review of the literature.
MedLine Citation:
PMID:  20671950     Owner:  NLM     Status:  In-Data-Review    
Background. Hypophysitis is an inflammatory disease of the pituitary gland that may mimic pituitary tumors clinically and radiologically. Case Description. We report a case of a xanthomatous hypophysitis initially diagnosed as pituitary adenoma. A 31-year-old woman presented with headache, diabetes insipidus, and amenorrhea. A head CT scan showed no intrasellar changes, while an MRI scan showed a sellar cystic mass. An endocrinological work up revealed mild hypocortisolism and diabetes insipidus (DI). Transsphenoidal surgery was performed. The intraoperative histological examination suggested a pituitary adenoma. The removed tissue showed central necrosis surrounded by accumulation of foamy cells and xanthomatous epithelioid cells. The patient made an uneventful postoperative recovery, Nevertheless, DI persisted and the adenohypophysis hypofunction did not recover. Conclusion. We describe an unusual inflammatory lesion of the pituitary gland mimicking an adenoma. A high level of clinical suspicion of inflammatory disorders is necessary for correct diagnosis and optimal management.
Laura Aste; Mattia Bellinzona; Veronica Meleddu; Graziella Farci; Cristina Manieli; Umberto Godano
Publication Detail:
Type:  Journal Article     Date:  2010-07-08
Journal Detail:
Title:  Journal of oncology     Volume:  2010     ISSN:  1687-8469     ISO Abbreviation:  J Oncol     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101496537     Medline TA:  J Oncol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  195323     Citation Subset:  -    
Department of Neurosurgery, Brotzu Hospital, Via Peretti 1, 09100 Cagliari, Italy.
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