Document Detail

Xanthomatous change in tumours of glial origin.
MedLine Citation:
PMID:  2177036     Owner:  NLM     Status:  MEDLINE    
Six patients with glial tumours showing xanthomatous change are reported here. Four patients in the series showed features of anaplastic (malignant) glioma or glioblastoma multiforme. In these patients, the astrocytic origin of the xanthomatous cells was confirmed by electron microscopy and immunohistochemistry using glial fibrillary acidic protein (GFAP). Of these, in one patient (no. 4) xanthomatous change was seen in an anaplastic (malignant) mixed glioma with significant ependymal component. Only one patient (no. 5) could be considered histologically as pleomorphic xanthoastrocytoma, but no clinical follow up was available. The value of immunohistochemical staining for GFAP in distinguishing gliomas with xanthomatous change from true xanthofibromas and xanthosarcomas was demonstrated in one patient (no. 6) in whom the glioblastomatous areas were GFAP positive but the xanthomatous areas were negative. This was therefore considered as a rare condition of glioblastoma with xanthosarcoma.
C Sarkar; S Roy; S Bhatia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Indian journal of medical research     Volume:  92     ISSN:  0971-5916     ISO Abbreviation:  Indian J. Med. Res.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-02-26     Completed Date:  1991-02-26     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0374701     Medline TA:  Indian J Med Res     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  324-31     Citation Subset:  IM    
Department of Pathology, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Astrocytoma / pathology
Central Nervous System Diseases / pathology*
Glioblastoma / pathology
Glioma / pathology
Nervous System Neoplasms / pathology*
Sarcoma / pathology
Xanthomatosis / pathology*

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