| Xanthoangelols isolated from Angelica keiskei inhibit inflammatory-induced plasminogen activator inhibitor 1 (PAI-1) production. | |
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MedLine Citation:
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PMID: 22038782 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The folk medicine Angelica keiskei (Ashitaba) exhibits antitumor, antioxidant and antidiabetic activities and it has recently attracted attention as a health food. Ashitaba is thought to have antithrombotic properties, but this has not yet been scientifically proven. The elevation of plasma plasminogen activator inhibitor 1 (PAI-1), an inhibitor of fibrinolysis results in a predisposition to the risk of thrombosis. The present study showed that Ashitaba exudates injected intraperitoneally and orally administered over long-term suppressed the lipopolysaccharide (LPS) induced PAI-1 increase in mouse plasma. We also found that xanthoangelol, xanthoangelols B and D, the components of Ashitaba exudates, significantly inhibited TNFα-induced PAI-1 production from human umbilical vein endothelial cells (HUVECs). These findings suggest that Ashitaba can decrease elevated PAI-1 production, and that daily consumption of Ashitaba product might maintain anticoagulant status by inhibiting elevations in PAI-1 under inflammatory conditions. |
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Authors:
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Naoki Ohkura; Yoshitaka Nakakuki; Masahiko Taniguchi; Shiho Kanai; Akiko Nakayama; Katsunori Ohnishi; Toshiyuki Sakata; Tomoyoshi Nohira; Juzo Matsuda; Kimiye Baba; Gen-Ichi Atsumi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-28 |
Journal Detail:
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Title: BioFactors (Oxford, England) Volume: - ISSN: 1872-8081 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807441 Medline TA: Biofactors Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 International Union of Biochemistry and Molecular Biology, Inc. |
Affiliation:
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Department of Clinical Molecular Biology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamihara, Kanagawa, Japan. n-ohkura@pharm.teikyo-u.ac.jp. |
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