Document Detail

Xanthine lithiasis, nephrocalcinosis, and renal failure in a leukemia patient treated with allopurinol.
MedLine Citation:
PMID:  3480085     Owner:  NLM     Status:  MEDLINE    
An 11-year-old boy who presented in acute renal failure with significant increases of uric acid and phosphorus in his serum was discovered to have acute lymphoblastic leukemia. Five years later, he had a second and similar episode of acute renal failure, which was responsive to hemodialysis. After three months of daily therapy with allopurinol, a third and final episode of renal failure was unresponsive to peritoneal dialysis. Autopsy revealed an obstructive uropathy; focal nephrocalcinosis; and multiple, small, tan calculi in the calyces of both kidneys. Systemic cryptococcosis was also discovered. The stones, characterized by paper chromatography, electrophoresis, x-ray diffraction, and infrared spectroscopy, were 82% xanthine, 15% oxypurinol, and 3% hypoxanthine. We suggest that attention to the effects of accelerated tumor-cell lysis may protect renal function in patients with a large and drug-sensitive tumor cell load. Similarly, early detection of the fungal complications of leukemic therapy is an essential component of the treatment program.
J L Potter; A A Silvidi
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical chemistry     Volume:  33     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-02-05     Completed Date:  1988-02-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2314-6     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, Children's Hospital Medical Center of Akron, OH 44308.
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MeSH Terms
Allopurinol / adverse effects*
Kidney Calculi / analysis,  etiology*
Kidney Failure, Acute / etiology*
Leukemia, Lymphoid / complications*
Phosphorus / blood
Uric Acid / blood
Xanthines / analysis*
Reg. No./Substance:
0/Xanthines; 315-30-0/Allopurinol; 69-89-6/Xanthine; 69-93-2/Uric Acid; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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