Document Detail


XRCC1 codon 399 and ERCC2 codon 751 polymorphism, smoking, and drinking and risk of esophageal squamous cell carcinoma in a North Indian population.
MedLine Citation:
PMID:  17556064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
XRCC1 (X-ray cross-complementing group 1) codon 399 and ERCC2 (excision repair cross-complementing group 2) codon 751 polymorphisms were studied in esophageal squamous cell carcinoma (ESQCC) in a North Indian population. Peripheral blood samples of 120 cases and 160 age-and-gender matching controls were collected from North India and the two polymorphisms were studied by means of polymerase chain reaction-restriction fragment length polymorphism techniques. The data were analyzed with a logistic regression model. The XRCC1 codon 399 Gln/Gln genotype was significantly associated with reduced risk of ESQCC (OR = 0.31, 95% CI = 0.12-0.78, P = 0.01). In smokers, the XRCC1 Arg/Gln genotype was marginally and statistically nonsignificantly (OR = 1.5) associated with increased risk of this cancer. In drinkers, the XRCC1 Gln/Gln genotype was significantly protective (OR = 0.06, 95% CI = 0.007-0.605, P = 0.03), whereas ERCC2 (Lys/Gln-Gln/Gln) was marginally associated with increased risk (OR = 2.1, 95% CI = 0.46-9.44). Upon analysis of gene-gene interaction, a relationship was observed, although statistically nonsignificant, between combined genotypes of XRCC1 (Arg/Gln-Gln/Gln)-ERCC2 Gln/Gln (OR = 0.33, 95% CI = 0.09-1.16) and XRCC1 (Gln/Gln)-ERCC2 (Lys/Gln) (OR = 0.36, 95% CI = 0.11-1.17) and reduced risk of ESQCC in the North Indian population. These observations suggest that the Gln/Gln genotype of XRCC1 might play an important role in DNA repair in ESQCC.
Authors:
Ranbir Chander Sobti; Jagmohan Singh; Pushpinder Kaur; Suparna S Pachouri; Ehtesham A Siddiqui; Harnish Singh Bindra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  175     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-08     Completed Date:  2007-08-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  91-7     Citation Subset:  IM    
Affiliation:
Department of Biotechnology, Panjab University, Chandigarh 160014, India. rcsobti@pu.ac.in
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / adverse effects*,  genetics
Carcinoma, Squamous Cell / etiology,  genetics*
Case-Control Studies
Codon / genetics
DNA Repair / genetics
DNA-Binding Proteins / genetics*
Esophageal Neoplasms / genetics*
Female
Genetic Predisposition to Disease
Humans
India
Male
Middle Aged
Polymorphism, Genetic*
Smoking / adverse effects*,  genetics
Xeroderma Pigmentosum Group D Protein / genetics*
Chemical
Reg. No./Substance:
0/Codon; 0/DNA-Binding Proteins; 0/X-ray repair cross complementing protein 1; EC 5.99.-/ERCC2 protein, human; EC 5.99.-/Xeroderma Pigmentosum Group D Protein

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