Document Detail

XPC gene intron 11 C/A polymorphism is a predictive biomarker for the sensitivity to NP chemotherapy in patients with non-small cell lung cancer.
MedLine Citation:
PMID:  20571354     Owner:  NLM     Status:  MEDLINE    
The fact that intron single nucleotide polymorphisms could regulate gene expression or even alter gene expression levels has been the focus of attention. To study the relationship between the intron 11 C/A single nucleotide polymorphism of XPC gene and the efficacy of vinorelbine and cisplatin (NP) chemotherapy, 164 patients with non-small cell lung cancer (NSCLC) taking NP chemotherapy drugs were evaluated according to the efficacy of the treatment. We used polymerase chain reaction restriction fragment length polymorphism to examine the C/A polymorphism in the XPC gene intron 11 of the DNA samples extracted from peripheral blood. It was found that the frequency of patients in the effective group with C/C+C/A genotype (37.6%) had significant difference to chemotherapy than that of patients with A/A homozygotes (27.7%) in the same group (P=0.043, odds ratio=2.366, 95% confidence interval=1.026-5.457). Therefore, NSCLC patients with the C/C+C/A genotype are more sensitive to NP treatment than those with the A/A genotype. The XPC gene intron 11 C/A polymorphism may be a predictive biomarker for sensitivity to NP chemotherapy in patients with NSCLC.
Li-Bo Zhu; Qian Xu; Cheng-Yu Hong; Zheng Yue; Ye Zhang; Hui-Nan Ye; Yuan Yuan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anti-cancer drugs     Volume:  21     ISSN:  1473-5741     ISO Abbreviation:  Anticancer Drugs     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100823     Medline TA:  Anticancer Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  669-73     Citation Subset:  IM    
Cancer Control Laboratory of Cancer Institute and General Surgery, First Affiliated Hospital of China Medical University, Shenyang, China.
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MeSH Terms
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carcinoma, Non-Small-Cell Lung / blood,  drug therapy*,  genetics
Cisplatin / therapeutic use*
DNA-Binding Proteins / blood,  genetics*
Drug Screening Assays, Antitumor
Genetic Markers
Lung Neoplasms / blood,  drug therapy*,  genetics
Middle Aged
Polymorphism, Single Nucleotide*
Treatment Outcome
Vinblastine / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Genetic Markers; 156533-34-5/XPC protein, human; 15663-27-1/Cisplatin; 71486-22-1/vinorelbine; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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