| XP-828L in the treatment of mild to moderate psoriasis: randomized, double-blind, placebo-controlled study. | |
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MedLine Citation:
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PMID: 18069904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: XP-828L, a protein extract obtained from sweet whey, has demonstrated potential benefit for the treatment of mild to moderate psoriasis in an open-label study. OBJECTIVE: To study in a randomized, double-blind, placebo-controlled study the safety and efficacy of XP-828L in the treatment of mild to moderate psoriasis. DESIGN: XP-828L 5 g/d (group A, n=42) or placebo (group B, n=42) was given orally for 56 days followed by XP-828L 5 g/d in group A and by XP-828L 10 g/d in group B for an additional 56 days. RESULTS: Patients receiving XP-828L 5 g/d for 56 days had an improved Physician's Global Assessment (PGA) score compared with patients under placebo (p less than 0.05). Considering the data of group A only, the PGA score improved from day 1 to day 56 (p less than 0.01); the Psoriasis Area and Severity Index score improved as well, but to a lesser extent (p less than 0.05). CONCLUSION: Oral administration of 5 g/d XP-828L compared with a placebo significantly improved the PGA score of patients with mild to moderate psoriasis. |
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Authors:
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Yves Poulin; Robert Bissonnette; Christina Juneau; Kim Cantin; Rejean Drouin; Patrice E Poubelle |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Alternative medicine review : a journal of clinical therapeutic Volume: 12 ISSN: 1089-5159 ISO Abbreviation: Altern Med Rev Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-11 Completed Date: 2008-02-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705340 Medline TA: Altern Med Rev Country: United States |
Other Details:
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Languages: eng Pagination: 352-9 Citation Subset: K |
Affiliation:
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Department of Medicine, Laval University, Quebec City, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Dermatologic Agents / adverse effects, therapeutic use* Double-Blind Method Female Humans Male Middle Aged Milk Proteins / adverse effects, therapeutic use* Psoriasis / drug therapy*, pathology Quebec Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Dermatologic Agents; 0/Milk Proteins; 0/XP-828l |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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