Document Detail

The XNA world: progress towards replication and evolution of synthetic genetic polymers.
MedLine Citation:
PMID:  22704981     Owner:  NLM     Status:  MEDLINE    
Life's diversity is built on the wide range of properties and functions that can be encoded in natural biopolymers such as polypeptides and nucleic acids. However, despite their versatility, the range of chemical functionalities is limited, particularly in the case of nucleic acids. Chemical modification of nucleic acids can greatly increase their functional diversity but access to the full phenotypic potential of such polymers requires a system of replication. Here we review progress in the chemical and enzymatic synthesis, replication and evolution of unnatural nucleic acid polymers, which promises to enable the exploration of a vast sequence space not accessible to nature and deliver ligands, catalysts and materials based on this new class of biopolymers.
Vitor B Pinheiro; Philipp Holliger
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-06-14
Journal Detail:
Title:  Current opinion in chemical biology     Volume:  16     ISSN:  1879-0402     ISO Abbreviation:  Curr Opin Chem Biol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-21     Completed Date:  2012-12-20     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9811312     Medline TA:  Curr Opin Chem Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  245-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
DNA / biosynthesis*,  chemistry,  genetics*
DNA Replication*
Evolution, Molecular*
Polymers / chemical synthesis*,  metabolism*
RNA / chemistry,  genetics*
Grant Support
MC_U105178804//Medical Research Council; U105178804//Medical Research Council
Reg. No./Substance:
0/Polymers; 63231-63-0/RNA; 9007-49-2/DNA

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