| X-linked inhibitor of apoptosis: a chemoresistance factor or a hollow promise. | |
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MedLine Citation:
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PMID: 20682709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The X-linked inhibitor of apoptosis (XIAP) is the only cellular protein that has evolved to potently inhibit the enzymatic activity of mammalian caspases and promotes resistance to apoptosis. Given its role in apoptosis and its frequently elevated expression in malignant cells, XIAP has garnered the most attention as a promising therapeutic target in cancer to overcome drug resistance. Accordingly, XIAP is thought to render tumor cells resistant to chemotherapy through its ability to inhibit caspases, and it is on this basis that XIAP has been proposed as an important adverse biomarker for chemoresistance in cancer patients. Here, the current understanding of the role of XIAP in cancer is reviewed. Further, the notion is explored that the elevated XIAP expression frequently observed in malignant tissues is, at least, not exclusively responsible for the resistance of tumor cells to conventional therapeutic treatment; rather, the function of XIAP seems to be conducive to the process of malignant transformation and/or progression. |
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Authors:
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Hamid Kashkar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-08-03 |
Journal Detail:
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Title: Clinical cancer research : an official journal of the American Association for Cancer Research Volume: 16 ISSN: 1078-0432 ISO Abbreviation: Clin. Cancer Res. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502500 Medline TA: Clin Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 4496-502 Citation Subset: IM |
Copyright Information:
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©2010 AACR. |
Affiliation:
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Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Köln, Germany. h.kashkar@uni-koeln.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / therapeutic use Cell Transformation, Neoplastic / genetics Drug Resistance, Neoplasm / genetics* Humans Models, Biological Molecular Targeted Therapy / methods*, trends Neoplasms / drug therapy*, genetics Therapies, Investigational / methods, trends Translational Research / methods, trends X-Linked Inhibitor of Apoptosis Protein / antagonists & inhibitors, genetics, metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/X-Linked Inhibitor of Apoptosis Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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