Document Detail

XC cell fusion by murine leukemia viruses: fusion from without.
MedLine Citation:
PMID:  187916     Owner:  NLM     Status:  MEDLINE    
Concentrated murine leukemia virus (MuLV) or MuLV producing cells induce XC cell fusion within an hour leading to syncytia formation. While MuLV inactivated by UV irradiation, beta-propiolactone or hydroxylamine treatment still caused cell fusion, Bromelin- or trypsin treated MuLV was no longer able to fuse XC cells. Though sonicated MuLV induced no XC cell fusion, it interfered with cell fusion as caused by untreated MuLV. XC cells infected by diluted MuLV of a titer lower than 1 X 10(5) PFU/ml formed no syncytia although they produced MuLV. The cell fusion mechanism is discussed.
H Ogura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical microbiology and immunology     Volume:  162     ISSN:  0300-8584     ISO Abbreviation:  Med. Microbiol. Immunol.     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-02-16     Completed Date:  1977-02-16     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  0314524     Medline TA:  Med Microbiol Immunol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  175-81     Citation Subset:  IM    
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MeSH Terms
Bromelains / pharmacology
Cell Fusion*
Cell Line
Friend murine leukemia virus / drug effects,  radiation effects
Hydroxylamines / pharmacology
Leukemia Virus, Murine* / drug effects,  radiation effects
Propiolactone / pharmacology
Sarcoma, Experimental
Trypsin / pharmacology
Ultraviolet Rays
Reg. No./Substance:
0/Hydroxylamines; 57-57-8/Propiolactone; 9001-00-7/Bromelains; EC

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