| X-ray induced translocations in premeiotic germ cells of monkeys. | |
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MedLine Citation:
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PMID: 1944375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The induction of reciprocal translocations by various X-ray exposures was studied in spermatogonial stem cells of rhesus monkeys (Macaca mulatta) and stump-tailed macaques (Macaca arctoides) by means of spermatocyte analysis many cell generations after irradiation. The yields of translocations recovered from irradiated stump-tailed macaques were lower than those observed in rhesus monkeys and represent in fact the lowest induction rates per Gy ever recorded for experimental mammals. In the rhesus monkey a humped dose-effect relationship was found with (a) a homogeneous response with (pseudo-)linear kinetics below 1 Gy, (b) much more variability at higher doses, and (c) no induction at all at doses of 4 Gy and above. It is suggested that the post-irradiation proliferation differentiation pattern of surviving rhesus monkey spermatogonial stem cells i mainly responsible for these characteristics of the dose-response curve. |
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Authors:
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P P van Buul |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mutation research Volume: 251 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1991-12-02 Completed Date: 1991-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 31-9 Citation Subset: IM |
Affiliation:
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Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratory, Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dose-Response Relationship, Radiation Macaca fascicularis Macaca mulatta Male Species Specificity Spermatocytes / radiation effects* Translocation, Genetic / radiation effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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