Document Detail

X-ray diffraction evidence of collagen molecular packing and cross-linking in fibrils of rat tendon observed by synchrotron radiation.
MedLine Citation:
PMID:  7188356     Owner:  NLM     Status:  MEDLINE    
X-ray diffraction patterns of fibres from 90 day (mature) rat-tail tendons were investigated using synchrotron radiation. The specimens were kept isometric at their corresponding in vitro rest length, and effects of pH and ionic strength were studied during short X-ray exposures. The results indicate that fibrils, equilibrated in physiological Ringer prior to exposure, have segregated lateral regions of well ordered collagen molecular packing. Lowering the ionic strength or the pH to 4.0 causes an order/disorder transition during which the fibril crystallinity decreases. At pH 3.5 a dramatic increase in the lateral swelling was observed. This effect was absent for fibres pretreated with sodium borohydride. The results are interpreted on the basis of cross-linking phenomena whereby the aldimine cross-link seems to be a controlling component of the lateral packing arrangement of collagen molecules.
K H Svendsen; M H Koch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The EMBO journal     Volume:  1     ISSN:  0261-4189     ISO Abbreviation:  EMBO J.     Publication Date:  1982  
Date Detail:
Created Date:  1984-07-27     Completed Date:  1984-07-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  669-74     Citation Subset:  IM    
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MeSH Terms
Collagen / analysis*
Hydrogen-Ion Concentration
Macromolecular Substances
Rats, Inbred Strains
Tendons / ultrastructure*
X-Ray Diffraction
Reg. No./Substance:
0/Macromolecular Substances; 9007-34-5/Collagen

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