Document Detail


X-linked variation in immune response in Drosophila melanogaster.
MedLine Citation:
PMID:  19822734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study quantifies the effects of naturally occurring X-linked variation on immune response in Drosophila melanogaster to assess associations between immunity genotypes and innate immune response. We constructed a set of 168 X-chromosomal extraction lines, incorporating X chromosomes from a natural population into co-isogenic autosomal backgrounds, and genotyped the lines at 88 SNPs in 20 X-linked immune genes. We find that genetic variation in many of the genes is associated with immune response phenotypes, including bacterial load and immune gene expression. Many of the associations act in a sex-specific or sexually antagonistic manner, supporting the theory that with the selective pressures facing genes on the X chromosome, sexually antagonistic variation may be more easily maintained.
Authors:
Erin M Hill-Burns; Andrew G Clark
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-10-12
Journal Detail:
Title:  Genetics     Volume:  183     ISSN:  1943-2631     ISO Abbreviation:  Genetics     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-09     Completed Date:  2010-02-18     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1477-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Infections / immunology
Drosophila melanogaster / genetics*,  immunology*,  microbiology
Female
Genes, X-Linked / genetics*
Genetic Variation*
Genotype
Male
Phenotype
Polymorphism, Single Nucleotide
Sex Characteristics
Species Specificity
Transcriptional Activation / immunology
Grant Support
ID/Acronym/Agency:
R01 AI064890/AI/NIAID NIH HHS; R01 AI064950/AI/NIAID NIH HHS; R01 AI064950-04/AI/NIAID NIH HHS
Comments/Corrections

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