| X-linked variation in immune response in Drosophila melanogaster. | |
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MedLine Citation:
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PMID: 19822734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study quantifies the effects of naturally occurring X-linked variation on immune response in Drosophila melanogaster to assess associations between immunity genotypes and innate immune response. We constructed a set of 168 X-chromosomal extraction lines, incorporating X chromosomes from a natural population into co-isogenic autosomal backgrounds, and genotyped the lines at 88 SNPs in 20 X-linked immune genes. We find that genetic variation in many of the genes is associated with immune response phenotypes, including bacterial load and immune gene expression. Many of the associations act in a sex-specific or sexually antagonistic manner, supporting the theory that with the selective pressures facing genes on the X chromosome, sexually antagonistic variation may be more easily maintained. |
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Authors:
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Erin M Hill-Burns; Andrew G Clark |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-10-12 |
Journal Detail:
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Title: Genetics Volume: 183 ISSN: 1943-2631 ISO Abbreviation: Genetics Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-09 Completed Date: 2010-02-18 Revised Date: 2012-05-28 |
Medline Journal Info:
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Nlm Unique ID: 0374636 Medline TA: Genetics Country: United States |
Other Details:
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Languages: eng Pagination: 1477-91 Citation Subset: IM |
Affiliation:
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Field of Genetics and Development, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. erinhill@life.bio.sunysb.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Infections / immunology Drosophila melanogaster / genetics*, immunology*, microbiology Female Genes, X-Linked / genetics* Genetic Variation* Genotype Male Phenotype Polymorphism, Single Nucleotide Sex Characteristics Species Specificity Transcriptional Activation / immunology |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI064890/AI/NIAID NIH HHS; R01 AI064950/AI/NIAID NIH HHS; R01 AI064950-04/AI/NIAID NIH HHS |
| Comments/Corrections | |
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