Document Detail


X inactivation and the complexities of silencing a sex chromosome.
MedLine Citation:
PMID:  19477626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
X chromosome inactivation represents a paradigm for monoallelic gene expression and epigenetic regulation in mammals. Since its discovery over half a century ago, the pathways involved in the establishment of X-chromosomal silencing, assembly, and maintenance of the heterochromatic state have been the subjects of intensive research. In placental mammals, it is becoming clear that X inactivation involves an interplay between noncoding transcripts such as Xist, chromatin modifiers, and factors involved in nuclear organization. Together these result in a changed chromatin structure and in the spatial reorganization of the X chromosome. Exciting new work is starting to uncover the factors involved in some of these changes. Recent studies have also revealed surprising diversity in the kinetics and extent of gene silencing across the X chromosome, as well as in the mechanisms of XCI between mammals.
Authors:
Jennifer Chow; Edith Heard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-05-26
Journal Detail:
Title:  Current opinion in cell biology     Volume:  21     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-05     Completed Date:  2009-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  359-66     Citation Subset:  IM    
Affiliation:
Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR3215, INSERM 934, 26 rue d'Ulm, Paris 75005, France. Jennifer.Chow@curie.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Gene Silencing*
RNA, Untranslated / genetics
X Chromosome*
X Chromosome Inactivation*
Chemical
Reg. No./Substance:
0/RNA, Untranslated

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