Document Detail


X-chromosome-counting mechanisms that determine nematode sex.
MedLine Citation:
PMID:  9217163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sex is determined in Caenorhabditis elegans by an X-chromosome-counting mechanism that reliably distinguishes the twofold difference in X-chromosome dose between males (1X) and hermaphrodites (2X). This small quantitative difference is translated into the 'on/off' response of the target gene, xol-1, a switch that specifies the male fate when active and the hermaphrodite fate when inactive. Specific regions of X contain counted signal elements whose combined dose sets the activity of xol-1. Here we ascribe the dose effects of one region to a discrete, protein-encoding gene, fox-1. We demonstrate that the dose-sensitive signal elements on chromosome X control xol-1 through two different molecular mechanisms. One involves the transcriptional repression of xol-1 in XX animals. The other uses the putative RNA-binding protein encoded by fox-1 to reduce the level of xol-1 protein. These two mechanisms of repression act together to ensure the fidelity of the X-chromosome counting process.
Authors:
M Nicoll; C C Akerib; B J Meyer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  388     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-07-24     Completed Date:  1997-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  200-4     Citation Subset:  IM    
Affiliation:
Department of Molecular and Cell Biology, University of California at Berkeley, 94720-3204, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans / genetics*,  physiology
Caenorhabditis elegans Proteins*
Chromosome Mapping
Gene Dosage
Gene Expression Regulation
Genes, Helminth*
Genes, Reporter
Helminth Proteins / genetics,  physiology
Hermaphroditism / genetics
Karyotyping
Male
Mutation
RNA-Binding Proteins / genetics,  physiology
Sex Differentiation / genetics*
Transcription, Genetic
X Chromosome*
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Helminth Proteins; 0/RNA-Binding Proteins; 161477-65-2/XOL-1 protein, C elegans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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