Document Detail


Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1.
MedLine Citation:
PMID:  11459829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the isolation and cloning of the Wrch-1 (Wnt-1 responsive Cdc42 homolog) cDNA. Wrch-1 is a novel gene whose mRNA level increases in response to Wnt-1 signaling in Wnt-1 transformed cells, Wnt-1 transgene induced mouse mammary tumors, and Wnt-1 retrovirus infected cells. Wrch-1 encodes a homolog of the Rho family of GTPases. It shares 57% amino acid sequence identity with Cdc42, but possesses a unique N-terminal domain that contains several putative PXXP SH3-binding motifs. Like Cdc42, Wrch-1 can activate PAK-1 and JNK-1, and induce filopodium formation and stress fiber dissolution. Active Wrch-1 stimulates quiescent cells to reenter the cell cycle. Moreover, overexpression of Wrch-1 phenocopies Wnt-1 in morphological transformation of mouse mammary epithelial cells. Taken together, Wrch-1 could mediate the effects of Wnt-1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation.
Authors:
W Tao; D Pennica; L Xu; R F Kalejta; A J Levine
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genes & development     Volume:  15     ISSN:  0890-9369     ISO Abbreviation:  Genes Dev.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-18     Completed Date:  2001-08-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1796-807     Citation Subset:  IM    
Affiliation:
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Cloning, Molecular
GTP-Binding Proteins / genetics*
Ganglia, Spinal
Gene Expression Regulation
Humans
Mice / embryology
Mitogen-Activated Protein Kinase 8
Mitogen-Activated Protein Kinases / metabolism
Molecular Sequence Data
Multigene Family
Protein-Serine-Threonine Kinases / metabolism
Proto-Oncogene Proteins / metabolism*
Sequence Homology, Amino Acid
Signal Transduction
Spinal Cord
Tissue Distribution
Trigeminal Ganglion
Wnt Proteins
Wnt1 Protein
Zebrafish Proteins*
p21-Activated Kinases
rho GTP-Binding Proteins*
Chemical
Reg. No./Substance:
0/Pak1 protein, mouse; 0/Proto-Oncogene Proteins; 0/WNT1 protein, human; 0/Wnt Proteins; 0/Wnt1 Protein; 0/Wnt1 protein, mouse; 0/Zebrafish Proteins; EC 2.7.11.1/PAK1 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/p21-Activated Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinase 8; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 3.6.1.-/GTP-Binding Proteins; EC 3.6.1.-/RHOU protein, human; EC 3.6.5.2/rho GTP-Binding Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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