Document Detail


Wound healing studies of Aristolochia bracteolata Lam. with supportive action of antioxidant enzymes.
MedLine Citation:
PMID:  13678243     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aristolochia bracteolata is a perennial herb, the leaves of which are used by the native tribals and villagers of the Chittoor District of Andhra Pradesh in India for the rapid healing of cuts and wounds. The ethanol extract of the shade-dried leaves of Aristolochia bracteolata Lam. was studied for its effect on wound healing in rats, using incision, excision and dead-space wound models, at two different dose levels of 400 and 800 mg/kg/body wt./day. The plant showed a definite, positive effect on wound healing, with a significant increase of the level of two powerful antioxidant enzymes, super oxide dismutase and catalase, in the granuloma tissue.
Authors:
A Shirwaikar; A P Somashekar; A L Udupa; S L Udupa; S Somashekar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  10     ISSN:  0944-7113     ISO Abbreviation:  Phytomedicine     Publication Date:  2003  
Date Detail:
Created Date:  2003-09-18     Completed Date:  2004-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  558-62     Citation Subset:  IM    
Affiliation:
Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal, India. annie.shirwaikar@cops.manipal.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / metabolism*
Aristolochia*
Catalase / biosynthesis
Female
India
Male
Medicine, Traditional
Phytotherapy*
Plant Extracts / administration & dosage,  pharmacology*,  therapeutic use
Plant Leaves
Rats
Skin / drug effects*,  enzymology,  injuries*,  pathology
Superoxide Dismutase / biosynthesis
Wound Healing / drug effects*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Plant Extracts; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase

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