Document Detail


Wound healing and local neuroendocrine regulation in the injured liver.
MedLine Citation:
PMID:  18442446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hepatic wound-healing response is a complex process involving many different cell types and factors. It leads to the formation of excessive matrix and a fibrotic scar, which ultimately disrupts proper functioning of the liver and establishes cirrhosis. Activated hepatic myofibroblasts, which are derived from cells such as hepatic stellate cells (HSCs), play a key role in this process. Upon chronic liver injury, there is an upregulation in the local neuroendocrine system and it has recently been demonstrated that activated HSCs express specific receptors and respond to different components of this system. Neuroendocrine factors and their receptors participate in a complex network that modulates liver inflammation and wound healing, and controls the development and progression of liver fibrosis. The first part of this review provides an overview of the molecular mechanisms governing hepatic wound healing. In the second section, we explore important components of the hepatic neuroendocrine system and their recently highlighted roles in HSC biology and hepatic fibrogenesis. We discuss the therapeutic interventions that are being developed for use in antifibrotic therapy.
Authors:
Mohammad R Ebrahimkhani; Ahmed M Elsharkawy; Derek A Mann
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-04-29
Journal Detail:
Title:  Expert reviews in molecular medicine     Volume:  10     ISSN:  1462-3994     ISO Abbreviation:  Expert Rev Mol Med     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-29     Completed Date:  2008-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939725     Medline TA:  Expert Rev Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  e11     Citation Subset:  IM    
Affiliation:
Cell signalling, Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Liver / cytology,  metabolism*,  pathology*
Neoplasms / metabolism,  pathology
Neurosecretory Systems / metabolism*
Signal Transduction
Wound Healing*
Grant Support
ID/Acronym/Agency:
//Medical Research Council; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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