Document Detail

Wound healing in the upper and lower extremities: a systematic review on the use of acellular dermal matrices.
MedLine Citation:
PMID:  23096978     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Use of biologically engineered acellular dermal matrices in the upper and lower extremities is increasingly recognized as a means of achieving definitive healing in the setting of both acute and chronic injuries but data and evidence supporting their use are limited. The authors performed this systematic review to identify all available evidence for the use of matrices in nonburn extremity reconstruction.
METHODS: A systematic review of the Cochrane and MEDLINE databases was performed to identify all reports of the application of matrices in wounds of the upper and lower extremities. Reports that included fewer than five patients and that involved cellular seeding, nonhuman studies, and burn injuries were excluded. Studies were evaluated for quality of statistical measures and outcomes, and a level of evidence was assigned in accordance with the American Society of Plastic Surgeons' Rating Levels of Evidence.
RESULTS: Of an initial 2422 reports, 13 primary reports were identified (10 case series and three randomized controlled trials) representing a total of 432 patients and 441 discrete wounds. After evidence review, 10 of these studies represented level IV evidence, two studies represented level II evidence, and one study achieved level I evidence.
CONCLUSIONS: Extremity wound management continues to rely on adequate vascular supply, débridement with eradication of infection, off-loading, and/or immobilization. Current data, although limited, appear to support the use of acellular dermal matrices in chronic and acute injuries where there is exposed bone, tendon, and/or muscle. They may provide a simple technique to achieve timely and durable tissue coverage in extremity wounds.
Matthew L Iorio; John Shuck; Christopher E Attinger
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  130     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-25     Completed Date:  2013-01-24     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232S-41S     Citation Subset:  AIM; IM    
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MeSH Terms
Acellular Dermis*
Arm / surgery*
Arm Injuries / surgery
Chondroitin Sulfates
Chronic Disease
Evidence-Based Medicine
Leg / surgery*
Leg Injuries / surgery
Leg Ulcer / surgery
Muscle, Skeletal / injuries,  surgery
Prospective Studies
Randomized Controlled Trials as Topic
Reconstructive Surgical Procedures / methods*
Retrospective Studies
Skin, Artificial
Soft Tissue Injuries / surgery
Tendon Injuries / surgery
Tissue Scaffolds
Treatment Outcome
Wound Healing*
Reg. No./Substance:
0/integra artificial skin; 9007-28-7/Chondroitin Sulfates; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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