Document Detail

Wound healing in sarcoma-bearing rats: tumor effects on cutaneous and deep wounds.
MedLine Citation:
PMID:  3573776     Owner:  NLM     Status:  MEDLINE    
Many surgeons think that cancer causes a higher incidence of wound complications. Wound healing was examined in a cutaneous and deep model in control and sarcoma-bearing rats to evaluate this concept. In a dorsal incisional wound, a significant decrease in wound breaking strength was observed from 19 days after tumor implantation onward. The amount of the breaking strength deficit increased with the size of tumor and the day post-tumor implant. In a deeper wound chamber, hydroxyproline levels, 3H-thymidine incorporation into DNA, histology, and collagen types were examined, and tumor produced no significant change in any parameter. The presence of tumor appeared to inhibit wound healing in cutaneous wounds but had no apparent effect on deeper wounds. This difference in healing in the two wound models is important to surgical oncologists. Because there is no demonstrable tumor-induced healing deficit in deep wounds, cancer-bearing organisms probably still heal these wounds normally.
W T Lawrence; J A Norton; A K Harvey; C M Gorschboth; T L Talbot; G R Grotendorst
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of surgical oncology     Volume:  35     ISSN:  0022-4790     ISO Abbreviation:  J Surg Oncol     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-23     Completed Date:  1987-06-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0222643     Medline TA:  J Surg Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
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MeSH Terms
Collagen / analysis
DNA / biosynthesis
Hydroxyproline / analysis
Rats, Inbred F344
Sarcoma, Experimental / chemically induced,  physiopathology*
Skin / injuries*
Tensile Strength
Wound Healing*
Reg. No./Substance:
51-35-4/Hydroxyproline; 56-49-5/Methylcholanthrene; 9007-34-5/Collagen; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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