Document Detail

Wound healing and formation of granulation tissue in normal and defibrinogenated rabbits. An experimental model and histological study.
MedLine Citation:
PMID:  7389767     Owner:  NLM     Status:  MEDLINE    
The aim of this investigation was to develop an experimental model for studies on the significance of fibrin deposition for wound healing. Systemic defirbinogenation with Arvin was used to achieve abnormal fibrin deposition in subcutaneously implanted cellulose sponges. The formation of granulation tissue in the sponges was studied histologically. Arvin injections resulted in a rapid decrease in plasma fibrinogen concentration with a concomittant rise in fibrin-degradation products. No change in FXIIIa activity was seen. During defibrinogenation an abnormal fibrin deposition was found in the sponges. The fibrin strands appeared irregular and disrupted. The number of fibroblasts and collagen fibrils was reduced in granulation tissue formed during defibrinogenation. The model used seems to allow controlled studies on the significance of fibrin deposition for wound healing. Defibrinogenation was found to influence granulation tissue formation.
S Brändstedt; F Rank; P S Olson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  12     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1980  
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  12-21     Citation Subset:  IM    
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MeSH Terms
Fibrin / physiology*
Fibrin Fibrinogen Degradation Products / analysis
Fibrinolytic Agents / pharmacology*
Granulation Tissue / drug effects,  pathology,  physiopathology*
Wound Healing / drug effects*
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Fibrinolytic Agents; 9001-31-4/Fibrin; 9004-34-6/Cellulose; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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