Document Detail


Wound healing. The effects of topical antimicrobial agents.
MedLine Citation:
PMID:  507884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of four commonly used topical antimicrobial agents on the rate of reepithelialization of clean wounds was evaluated in white domestic pigs. Neosporin Ointment was found to significantly increase the rate of reepithelialization by 25%, while Furacin significantly retarded the healing rate by 24%. Pharmadine, a preparation containing povidone-iodine, did not affect the rate of healing. Both Silvadene and its vehicle significantly increased the rate of reepithelialization by 28% and 21%, respectively. The effects of these agents cannot be explained on the basis of their antimicrobial activity.
Authors:
R G Geronemus; P M Mertz; W H Eaglstein
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  115     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-01-28     Completed Date:  1980-01-28     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1311-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Infective Agents, Local / administration & dosage*
Drug Combinations
Iodine / administration & dosage
Neomycin / administration & dosage
Nitrofurazone / administration & dosage
Ointments
Petrolatum / administration & dosage
Polymyxin B / administration & dosage
Povidone-Iodine / administration & dosage
Silver Sulfadiazine / administration & dosage
Swine
Time Factors
Wound Healing / drug effects*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Drug Combinations; 0/Ointments; 1404-04-2/Neomycin; 1404-26-8/Polymyxin B; 22199-08-2/Silver Sulfadiazine; 25655-41-8/Povidone-Iodine; 59-87-0/Nitrofurazone; 7553-56-2/Iodine; 8009-03-8/Petrolatum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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